<i>N</i> -Acetyl-Cysteinylated Streptophenazines from <i>Streptomyces</i>
Kristiina Vind, Sonia I. Maffioli, Blanca Fernandez-Ciruelos, Valentin Waschulin, Cristina Brunati, Matteo Simone, Margherita Sosio, Stefano Donadio
Abstract
-acetyl-cysteine moiety derives from cellular functions, most likely from mycothiol. Overall, our data represent an interesting example of how to leverage metabolomics for the discovery of new natural products and point out the often-neglected contribution of house-keeping cellular functions to natural product diversification.
Topics & Concepts
StreptomycesGene clusterBiologyNatural productStreptomycetaceaeMoietyActinomycetalesBiochemistryMetabolomicsStereochemistryBacteriaChemistryGeneGeneticsBioinformaticsMicrobial Natural Products and BiosynthesisGenomics and Phylogenetic StudiesMetabolomics and Mass Spectrometry Studies