Emerging mRNA therapies for cardiac fibrosis
Blake D. Jardin, Jonathan A. Epstein
Abstract
Cardiac fibrosis has few specific interventions available for effective treatment. mRNA encapsulated in lipid nanoparticles could provide a novel solution for treating cardiac fibrosis. This AJP perspective discusses what possible strategies could rely on this technology, from in vivo-produced CAR T cells that kill pathological fibroblasts to in vivo-produced T regulatory cells that dampen the concomitant profibrotic inflammatory cells contributing to remodeling, directly targeting fibroblasts and eliminating them or silencing profibrotic pathways.
Topics & Concepts
FibrosisCardiac fibrosisParacrine signallingMedicineFibroblastBioinformaticsCancer researchBiologyReceptorPathologyInternal medicineIn vitroBiochemistryCAR-T cell therapy researchViral Infections and Immunology ResearchIntegrated Circuits and Semiconductor Failure Analysis