Dirhodium tetraacetate binding to a B-DNA double helical dodecamer probed by X-ray crystallography and mass spectrometry
Gabriella Tito, Romualdo Troisi, Giarita Ferraro, Andrea Geri, Lara Massai, Luigi Messori, Filomena Sica, Antonello Merlino
Abstract
axial coordination. Complementary information has been gained through ESI MS measurements. Comparison between the present data and those previously obtained for cisplatin indicates that the two metallodrugs react with this DNA dodecamer in a significantly different fashion.
Topics & Concepts
Dodecameric proteinChemistryDNAAdductMass spectrometryCrystallographyX-rayStereochemistryBiochemistryOrganic chemistryQuantum mechanicsPhysicsChromatographyDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesMetal complexes synthesis and properties