HIV Skews a Balanced Mtb-Specific Th17 Response in Latent Tuberculosis Subjects to a Pro-inflammatory Profile Independent of Viral Load
Srabanti Rakshit, Nitin Hingankar, Shuba Varshini Alampalli, Vasista Adiga, Bharath K. Sundararaj, Pravat Nalini Sahoo, Greg Finak, Anto Jesuraj Uday Kumar J, Chirag Dhar, George D′Souza, Rashmi Virkar, Manisha Ghate, Madhuri Thakar, Ramesh Paranjape, Stephen C. De Rosa, Tom H. M. Ottenhoff, Annapurna Vyakarnam
Abstract
T cells, the associated dysregulation of Mtb-specific T cell homeostasis can potentially enhance the onset of TB in LTBI subjects.
Topics & Concepts
ImmunologyLatent tuberculosisTuberculosisMycobacterium tuberculosisMedicineViral loadImmune systemImmunityT cellVirologyInterleukin 17InterferonHuman immunodeficiency virus (HIV)PathologyTuberculosis Research and EpidemiologyImmunodeficiency and Autoimmune DisordersMycobacterium research and diagnosis