Design, synthesis and anticancer activity of novel valproic acid conjugates with improved histone deacetylase (HDAC) inhibitory activity
Tarek S. Ibrahim, Taghreed A. Sheha, Nader E. Abo‐Dya, Mohammed A. AlAwadh, Nabil A. Alhakamy, Zakaria K. Abdel‐Samii, Siva S. Panda, Gamal El‐Din A. Abuo‐Rahma, Mamdouh F. A. Mohamed
Topics & Concepts
ChemistryHeLaConjugateIn vitroHydrazideHistone deacetylaseValproic AcidIn vivoCell cultureHydroxamic acidIC50MTT assayCytotoxicityPharmacologyBiochemistryStereochemistryHistoneMedicineMathematical analysisGeneticsBiologyPsychiatryMathematicsOrganic chemistryEpilepsyGeneBiotechnologyHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsCatalytic C–H Functionalization Methods