Oligodendrocyte-derived extracellular vesicles as antigen-specific therapy for autoimmune neuroinflammation in mice
Giacomo Casella, Javad Rasouli, Alexandra Boehm, Weifeng Zhang, Dan Xiao, Larissa Lumi Watanabe Ishikawa, Rodolfo Thomé, Xing Li, Daniel Hwang, Patrizia Porazzi, Sudheer K. Molugu, Hsin‐Yao Tang, Guang‐Xian Zhang, Bogoljub Ćirić, Abdolmohamad Rostami
Abstract
T cells. Furthermore, we showed that human Ols also released EVs containing most relevant myelin Ags, providing a basis for their use in MS therapy. These findings introduce an approach for suppressing central nervous system (CNS) autoimmunity in a myelin Ag-specific manner, without the need to identify the target Ag.
Topics & Concepts
Extracellular vesiclesNeuroinflammationImmune systemAntigenMultiple sclerosisOligodendrocyteImmunologyExtracellularExperimental autoimmune encephalomyelitisAutoimmunityCell biologyMedicineBiologyChemistryMyelinNeuroscienceCentral nervous systemInflammationExtracellular vesicles in diseaseReproductive System and PregnancyMicroRNA in disease regulation