Diagnostic Accuracy of SARS-CoV-2 Rapid Antigen Detection Testing in Symptomatic and Asymptomatic Children in the Clinical Setting
Arnaud G. L’Huillier, Matthieu Lacour, Debora Sadiku, Mehdi A. Gadiri, Loraine De Siebenthal, Manuel Schibler, Isabella Eckerle, Selina Pinösch, Laurent Kaiser, Alain Gervaix, Alban Glangetas, Annick Galetto-Lacour, Laurence Lacroix
Abstract
= 0.09). In asymptomatic participants, the P-RDT displayed a sensitivity of 0.43 (95% CI 0.26 to 0.61). Specificity was 1.00 in symptomatic and asymptomatic children (95% CI 0.99 to 1.00). The overall 73% and 43% sensitivities of P-RDT in symptomatic and asymptomatic children, respectively, was below the 80% cutoff recommended by the World Health Organization. We observed a correlation between VL and P-RDT sensitivity, as well as variation of sensitivity according to DPOS, a major determinant of VL. These data highlight the limitations of RDTs in children, with the potential exception in early symptomatic children ≥12yrs.