The effect of lipid metabolism on age-associated cognitive decline: Lessons learned from model organisms and human
Shihao Wu, Xiaoli Liu, Haiyan Yang, Wenlin Ma, Zhao Qin
Abstract
Lipids are required as integral building blocks of cells to support cellular structures and functions. The intricate mechanisms underpinning lipid homeostasis are essential for the health and maintenance of the central nervous system. Here we summarize the recent advances in dissecting the effect of lipid metabolism on cognitive function and its age-associated decline by reviewing relevant studies ranging from invertebrate model organisms to mammals including human.
Topics & Concepts
UnderpinningLipid metabolismBiologyCognitionCognitive declineNeuroscienceFunction (biology)Lipid accumulationModel organismEcologyComputational biologyEvolutionary biologyMedicineDiseaseBiochemistryDementiaEngineeringInternal medicineGeneCivil engineeringDiet and metabolism studiesFatty Acid Research and HealthMitochondrial Function and Pathology