Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains
Arwen W. Gao, Gaby El Alam, Amélia Lalou, Terytty Yang Li, Marte Molenaars, Yunyun Zhu, Katherine A. Overmyer, Evgenia Shishkova, Kevin van den Hof, Maroun Bou Sleiman, Riekelt H. Houtkooper, Joshua J. Coon, Johan Auwerx
Abstract
were required for Dox-induced UPRmt and longevity in N2 and CB4856 worms, respectively. Our data have translational value as they indicate that the beneficial effects of Dox-induced UPRmt on lifespan are consistent across different genetic backgrounds through different regulators.
Topics & Concepts
TranscriptomeLipidomeBiologyProteomeComputational biologySystems biologyProteostasisGeneticsBioinformaticsGeneLipidomicsGene expressionGenetics, Aging, and Longevity in Model OrganismsMitochondrial Function and PathologyBiochemical Acid Research Studies