Attenuation of tonic inhibition prevents chronic neurovascular impairments in a Thy1-ChR2 mouse model of repeated, mild traumatic brain injury
James Mester, Paolo Bazzigaluppi, Adrienne Dorr, Tina L. Beckett, Matthew J. Burke, JoAnne McLaurin, John G. Sled, Bojana Stefanovic
Abstract
Our findings indicate that repeated mTBI leads to dramatic changes in the neurovascular unit function and that attenuation of tonic inhibition can prevent these alterations. The sustained disruption of the neurovascular function may underlie the concussed brain's long-term susceptibility to injury, and calls for development of better functional assays as well as of neurovascularly targeted interventions.
Topics & Concepts
Tonic (physiology)Neurovascular bundleTraumatic brain injuryNeuroscienceChronic traumatic encephalopathyMedicineAnesthesiaPsychologyConcussionAnatomyPoison controlPsychiatryInjury preventionEnvironmental healthTraumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchCardiac Arrest and Resuscitation