Recombinant oncolytic adenovirus expressing a soluble PVR elicits long-term antitumor immune surveillance
Hailin Zhang, Yonghui Zhang, Jie Dong, Binghua Li, C. F. Xu, Min Wei, Junhua Wu, Jiwu Wei
Abstract
T cells and the release of interferon (IFN)-γ, exhibiting an antitumor effect with long-term tumor-specific immune surveillance. In line with this, Ad5sPVR also effectively improved antitumor outcomes in solid tumors. In conclusion, while Ad5sPVR plays a role in oncolysis and transforms cold tumors into hot tumors, sPVR expressed by Ad5sPVR can block the PVR/TIGIT checkpoint and activate CD226, thereby greatly improving the efficacy of OVT. This study provides a new way to develop potential oncolytic viral drugs.
Topics & Concepts
TIGITOncolytic virusBiologyCancer researchImmune systemCD8Immune checkpointVirotherapyImmunotherapyCell biologyVirologyImmunologyVirus-based gene therapy researchCAR-T cell therapy researchViral gastroenteritis research and epidemiology