Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies
Isis Wolf, Christian Gratzke, Philipp Wolf
Abstract
Despite decades of research and successful improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. In recent years, it has become clear that PC stem cells (PCSCs) are the driving force in tumorigenesis, relapse, metastasis, and therapeutic resistance of PC. In this minireview, we discuss the impact of PCSCs in the clinical practice. Moreover, new therapeutic approaches to combat PCSCs are presented with the aim to achieve an improved outcome for patients with PC.
Topics & Concepts
Prostate cancerMedicineCarcinogenesisCancer stem cellMetastasisOncologyCancerStem cellCancer researchTargeted therapyInternal medicineBioinformaticsBiologyGeneticsCancer Cells and MetastasisProstate Cancer Treatment and ResearchFOXO transcription factor regulation