Visible Light-Assisted Photocatalyst-Free Tandem Sulfonylation/ Cyclization for the Synthesis of Oxindoles

Abstract

Oxindole derivatives are well developed in many fields, and this special heterocyclic scaffold is more and more widely used in natural products and bioactive molecules due to its unique functionality.Therefore, it is very important to explore new synthesis methods for this motif.A visible light-assisted photocatalyst-free protocol for the efficient synthesis of sulfonylated oxindoles under mild condition was reported.The present method starts from simple and readily available N-arylacrylamide and sodium sulfinates, uses cheap K2S2O8 as oxidant, and features moderate to good yields and excellent functional group tolerance.

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