Polyphyllin I reverses the resistance of osimertinib in non-small cell lung cancer cell through regulation of PI3K/Akt signaling
Lei Lai, Qiuping Shen, Yingjie Wang, Liting Chen, Jianjun Lai, Zhibing Wu, Hao Jiang
Topics & Concepts
OsimertinibProtein kinase BPI3K/AKT/mTOR pathwayLung cancerIn vivoT790MCancer researchApoptosisPharmacologyMedicineChemistryCancerBiologyInternal medicineEpidermal growth factor receptorBiochemistryBiotechnologyErlotinibGefitinibLung Cancer Treatments and MutationsPI3K/AKT/mTOR signaling in cancerCancer Mechanisms and Therapy