JAK inhibition in early-onset somatic, nonclonal STAT5B gain-of-function disease
Rachel Eisenberg, Melissa Gans, Timothy Ronan Leahy, Florian Gothe, Candice Perry, Mark Raffeld, Liqiang Xi, Sarah A. Blackstone, Chi Ma, Sophie Hambleton, Joshua D. Milner
Topics & Concepts
Janus kinasestatSTAT proteinSomatic cellBiologyJAK-STAT signaling pathwayGain of functionCancer researchImmunologyHypereosinophiliaPhenotypeGermlineHaematopoiesisSignal transductionEosinophiliaSTAT3GeneticsGeneStem cellTyrosine kinaseEosinophilic Disorders and SyndromesImmunodeficiency and Autoimmune DisordersCytokine Signaling Pathways and Interactions