The ER chaperone calnexin controls mitochondrial positioning and respiration
Tomás Gutiérrez, Hong Qi, Megan C. Yap, Nasser Tahbaz, Leanne Milburn, Eliana Lucchinetti, Phing‐How Lou, Michael Zaugg, Paul LaPointe, Pascal Mercier, Michael Overduin, Helmut Bischof, Sandra Burgstaller, Roland Malli, Klaus Ballanyi, Jianwei Shuai, Thomas Simmen
Abstract
was available for mitochondria, a key determinant for mitochondrial bioenergetics. Calnexin-deficient cells compensated for the loss of this function by partially shifting energy generation to the glycolytic pathway. These cells also showed closer apposition between the ER and mitochondria. Calnexin therefore controls the cellular energy balance between oxidative phosphorylation and glycolysis.
Topics & Concepts
CalnexinChaperone (clinical)Cell biologyMitochondrionRespirationBiologyEndoplasmic reticulumCalreticulinAnatomyMedicinePathologyMitochondrial Function and PathologyEndoplasmic Reticulum Stress and DiseaseAdipose Tissue and Metabolism