Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis
Yang Li, Jin Chen, Jianqing Liang, Yufeng Zhang, Qingzhe Wang, Xiaojun Ren, Jinsong Wei, Qian-Chun Gong, Jiting Zhang, Ning Jiang, Xinhua Lin, Jin Li, Bing Zhao
Abstract
Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis
Topics & Concepts
HepatoblastomaOrganoidCarcinogenesisDevelopmental biologyBiologyYAP1FetusPlacentationCell biologyCancer researchGeneticsTranscription factorGeneInternal medicineMedicinePregnancyPlacentaHippo pathway signaling and YAP/TAZLipid metabolism and biosynthesisWnt/β-catenin signaling in development and cancer