Pattern Separation in the Human Hippocampus: Response to Quiroga

Abstract

In a recent article [ 1. Quiroga R.Q. No pattern separation in the human hippocampus. Trends Cogn. Sci. 2020; 24: 994-1007 Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar ], Quiroga argues that there is no pattern separation in the human hippocampus based on data from human single-neuron studies. Quiroga argues instead that the hippocampus codes memories by coactivation of invariant and context-independent engrams. We believe that both pattern separation and completion are important components of human memory, and that overlooked empirical studies and theoretical considerations fundamentally challenge the arguments posed.

Topics & Concepts