IKKε phosphorylates kindlin-2 to induce invadopodia formation and promote colorectal cancer metastasis
Ge Liu, Yantao Bao, Chaohua Liu, Qinchang Zhu, Lin Zhao, Xiaopeng Lu, Qian Zhu, Yafei Lv, Feng Bai, Wen He, Yujie Sun, Wei‐Guo Zhu
Abstract
: We identify IKKε as a novel regulator of invadopodia formation and a unique mechanism by which IKKε promotes the metastasis of CRC. Our study suggests that IKKε is a potential target to suppress CRC metastasis.
Topics & Concepts
InvadopodiaMetastasisColorectal cancerPhosphorylationCancer researchCancerCell biologyMedicineChemistryBiologyInternal medicineCell Adhesion Molecules ResearchUbiquitin and proteasome pathwaysSignaling Pathways in Disease