Mechanistic Insights into Zika Virus NS3 Helicase Inhibition by Epigallocatechin-3-Gallate
Deepak Kumar, Nitin Sharma, Murali Aarthy, Sanjeev Kumar Singh, Rajanish Giri
Abstract
value of 295.7 nM and Ki of 0.387 ± 0.034 μM. Our study suggests the possibility that EGCG could be considered as a prime backbone molecule for further broad-spectrum inhibitor development against ZIKV and other flaviviruses.
Topics & Concepts
Zika virusHelicaseNS3VirologyDocking (animal)Viral replicationChemistryEpigallocatechin gallateRNAVirusBiologyBiochemistryPolyphenolMedicineAntioxidantHepatitis C virusNursingGeneMosquito-borne diseases and controlMalaria Research and ControlInsect symbiosis and bacterial influences