Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression
Che-Chung Lin, I‐Ying Kuo, Liting Wu, Wen‐Hui Kuan, Shengyou Liao, Jayu Jen, You-En Yang, Chengwei Tang, Yi‐Rong Chen, Yi‐Ching Wang
Abstract
These findings highlight the mechanism by which dysregulation of Kras/YY1/ZNF322/Shh transcriptional axis enhances neo-angiogenesis and cancer progression in lung cancer. Therapeutic strategies that target Kras/YY1/ZNF322A/Shh signaling axis may provide new insight on targeted therapy for lung cancer patients.
Topics & Concepts
Lung cancerAngiogenesisKRASCancer researchYY1MedicineCancerOncologyBiologyInternal medicinePromoterColorectal cancerGeneGene expressionGeneticsEpigenetics and DNA MethylationCancer-related gene regulationCancer-related molecular mechanisms research