Targeting the inflammasome in Parkinson’s disease
Qi Su, Wei Lun Ng, Suh Yee Goh, Muhammad Yaaseen Gulam, Lin‐Fa Wang, Eng‐King Tan, Matae Ahn, Yinxia Chao
Abstract
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases in which neuroinflammation plays pivotal roles. An important mechanism of neuroinflammation is the NLRP3 inflammasome activation that has been implicated in PD pathogenesis. In this perspective, we will discuss the relationship of some key PD-associated proteins including α-synuclein and Parkin and their contribution to inflammasome activation. We will also review promising inhibitors of NLRP3 inflammasome pathway that have potential as novel PD therapeutics. Finally, we will provide a summary of current and potential in vitro and in vivo models that are available for therapeutic discovery and development.