Policy Statement: Antibiotic Stewardship in Pediatrics
Jeffrey S. Gerber, Mary Anne Jackson, Pranita D. Tamma, Theoklis E. Zaoutis, Yvonne Maldonado, Sean T. O’Leary, Ritu Banerjee, Elizabeth D. Barnett, James D. Campbell, Mary T. Caserta, Jeffrey S. Gerber, Athena P. Kourtis, Ruth Lynfield, Flor M. Muñoz, Dawn Nolt, Ann‐Christine Nyquist, Sean T. O’Leary, William J. Steinbach, Ken Zangwill, Theoklis E. Zaoutis, David W. Kimberlin, Mark H. Sawyer, Henry H. Bernstein, H. Cody Meissner, Amanda Cohn, Karen M. Farizo, Marc Anthony Fischer, Natasha Halasa, Nicole Le Saux, Eduardo Lopez, Scot B. Moore, Neil S. Silverman, Judith Steinberg, Jeffrey R. Starke, James Stevermer, Kay M. Tomashek, Jennifer M. Frantz, Jason G. Newland, Rana Hamdy, Mayssa Abuali, Daniel Adams, Ritu Banerjee, Fernando Bula-Rudas, Dhanya Dharmapalan, Daniel E. Dulek, Dustin D. Flannery, Bishara J. Freij, Andrew B. Gainey, Jeffrey S. Gerber, Carol Glaser, Lori Handy, Benjamin Hanisch, Sara A. Healy, Adam L. Hersh, David Y. Hyun, Candace Johnson, Sophie E. Katz, Matthew P. Kronman, John J. Manaloor, Holly Maples, Lee Morris, Ben Onankpa, Ronda Oram, Debra L. Palazzi, Hayden T. Schwenk, Craig Shapiro, Prachi Singh, Kevin B. Spicer, Pranita D. Tamma, Michael TeKippe, Emily Thorell, Alison C. Tribble, Zachary Willis, Jon S. Woods, Tracy N. Zembles, Terri Christene Phillips
Abstract
Antibiotic overuse contributes to antibiotic resistance, which is a threat to public health. Antibiotic stewardship is a practice dedicated to prescribing antibiotics only when necessary and, when antibiotics are considered necessary, promoting the use of the appropriate agent(s), dose, duration, and route of therapy to optimize clinical outcomes while minimizing the unintended consequences of antibiotic use. Because there are differences in common infectious conditions, drug-specific considerations, and the evidence surrounding treatment recommendations (eg, first-line therapy and duration of therapy) between children and adults, this statement provides specific guidance for the pediatric population. This policy statement discusses the rationale for inpatient and outpatient antibiotic stewardship programs (ASPs); essential personnel, infrastructure, and activities required; approaches to evaluating their effectiveness; and gaps in knowledge that require further investigation. Key guidance for both inpatient and outpatient ASPs are provided.