M2 Macrophage Membrane‐Mediated Biomimetic‐Nanoparticle Carrying COX‐siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation (Small 33/2023)
Jie Sun, Fei Ju, Jing Jin, Hao Liang Wang, Zhi Jie Li, Yucheng Sun, Qing Zhong Chen, Qian Yang, Jun Tan, You Lang Zhou
Abstract
Targeted Delivery Systems Jun Tan, You Lang Zhou, and co-workers construct successfully an M2M@PLGA/COX-siRNA delivery system and measure its targeting properties and therapeutic effects on a rat model of flexor digitorum longus (FDL) tendon injury combined with rotator cuff injury. Treatment outcomes indicate that the M2M@PLGA delivery system could provide an effective biological strategy for preventing multiple tendon adhesions. More details can be found in article number 2300326.
Topics & Concepts
TendonPLGAInflammationMacrophageSmall interfering RNADelivery systemCancer researchCell biologyChemistryTransfectionMedicineBiomedical engineeringNanoparticleImmunologySurgeryBiologyNanotechnologyMaterials scienceIn vitroBiochemistryGeneTendon Structure and TreatmentOrthopedic Surgery and RehabilitationShoulder Injury and Treatment