O-Fucosylation of ADAMTSL2 is required for secretion and is impacted by geleophysic dysplasia-causing mutations
Ao Zhang, Steven J. Berardinelli, Christina Leonhard-Melief, Deepika Vasudevan, Ta-Wei Liu, Andrew Taibi, Sharee Giannone, Suneel Apte, Bernadette C. Holdener, Robert S. Haltiwanger
Abstract
fucosylation on TSR3 and impaired ADAMTSL2 secretion.
Topics & Concepts
FucosylationBiologyGlycosylationMolecular biologyMatricellular proteinGeneticsThrombospondinFucoseGlycoproteinMetalloproteinaseExtracellular matrixMatrix metalloproteinaseGlycosylation and Glycoproteins ResearchGalectins and Cancer BiologyConnective tissue disorders research