Effects of “Bacuri” Seed Butter (Platonia insignis Mart.), a Brazilian Amazon Fruit, on Oxidative Stress and Diabetes Mellitus-Related Parameters in STZ-Diabetic Rats
Jéssica Vanessa dos Santos Lindoso, Severino R M de Alencar, Andressa Amorim dos Santos, Renato Sampaio Mello Neto, Ana Victória da Silva Mendes, Mariely Mendes Furtado, Maísa Gomes da Silva, Ana Karolinne da Silva Brito, Emanuelle Karine Frota Batista, Sílvia de Araújo França Baêta, Paulo Humberto Moreira Nunes, Massimo Lucarini, Alessandra Durazzo, Daniel Dias Rufino Arcanjo, Maria do Carmo de Carvalho e Martins
Abstract
Mart. ("bacuri") seed butter (BSB) on oxidative stress and diabetes mellitus-related parameters in streptozotocin-induced (STZ) diabetic rats. Diabetes mellitus was induced in female Wistar rats (180-250 g) by the intraperitoneal administration of STZ (45 mg/kg, b.w). BSB (25, 50, and 100 mg/kg) was administered to animals for four weeks. The effect on weight gain, food intake, blood glucose, glycated hemoglobin, hepatic transaminases, plasma and liver TBARS and MPO activity, erythrocyte SOD activity, non-protein sulfhydryl groups (SH-NP), and histopathology of the liver tissue was investigated. BSB at the dose of 100 mg/kg had a positive effect on the reduction in glycated hemoglobin percentage and increased albumin concentration, as well as decreased ALT and AST levels and increased SH-NP liver levels in treated animals compared to normal control rats. Moreover, BSB had no effects on weight gain, food intake, and fasting glucose. Thus, the BSB presented marked properties in improvement of hepatic antioxidant defenses, which demonstrates BSB as a potential hepatoprotective agent in metabolic disorders.