Lateral septum modulates cortical state to tune responsivity to threat stimuli
Mariko Hashimoto, Salvador Ignacio Brito, Anne Venner, Amanda Loren Pasqualini, Tracy Yang, David Frank Allen, Sarah J. Stankowicz, Patrick M. Fuller, Todd E. Anthony
Abstract
activity tracks brain state fluctuations and drives cortical activation and rapid awakening in the absence of threat. Together, our findings suggest that LS directs bottom-up modulation of cortical function to evoke preparatory defensive internal states and selectively enhance responsivity to threat-related stimuli.
Topics & Concepts
Stimulus (psychology)NeuroscienceArousalStimulationPsychologyPerceptionAversive StimulusCognitive psychologyNeural dynamics and brain functionNeurobiology and Insect Physiology ResearchNeuroendocrine regulation and behavior