Overexpressed DEPDC1B contributes to the progression of hepatocellular carcinoma by CDK1
Xiaowei Dang, Qi Pan, Zhen-Hai Lin, Hao‐Hao Wang, Lu-Hao Li, Lin Li, Dongqi Shen, Pei-Ju Wang
Abstract
BACKGROUND: Hepatocellular carcinoma (HCC) is the main type of primary liver cancer and shows a heavy burden worldwide. Its recurrence and mortality rate are still uncontrolled by the usage of present treatments. More attention has been focused on exploring specific genes that play important roles in HCC procession, and the function of DEP domain containing 1B (DEPDC1B) in HCC has not been researched. METHODS: . RESULTS: . CONCLUSIONS: , and it can interact with CDK1 and rescued by CDK1. The study suggested that DEPDC1B was as a potential therapeutic target involved in HCC growth and progression.
Topics & Concepts
Gene knockdownCyclin-dependent kinase 1Cell growthCancer researchFlow cytometryCell cycleApoptosisIn vivoMTT assayCell cycle checkpointCellBiologyMolecular biologyGeneticsBiotechnologyBiochemistryFerroptosis and cancer prognosisCancer-related Molecular PathwaysEpigenetics and DNA Methylation