A novel FAP-targeting antibody-exatecan conjugate improves immune checkpoint blockade by reversing immunosuppressive microenvironment in pancreatic cancer
Xiaobao Wei, Jiangchao Wu, Wanyue Cao, Qitai Chen, Zhenduo Shao, Cheng‐Yang Hu, Yize Zhang, Weining Weng, Tao Meng, Xun Meng, Tingbo Liang, Qi Zhang
Topics & Concepts
Cancer researchPancreatic cancerTumor microenvironmentIn vivoAntibody-drug conjugateImmune checkpointImmune systemBiologyImmunotherapyAntibodyPancreatic tumorImmunotoxinStromaImmunosuppressionBlockadeCancerCytotoxicityTumor-infiltrating lymphocytesCancer cellPharmacologyT cellImmunologyMedicineTransplantationCancer-Associated FibroblastsIn vitroDownregulation and upregulationCytotoxic T cellGemcitabineApoptosisPD-L1Cancer immunotherapyTumor progressionElectrochemotherapyEx vivoFOXP3CellPeptidase Inhibition and AnalysisPancreatic and Hepatic Oncology ResearchUbiquitin and proteasome pathways