Electrochemical and Mechanistic Study of Oxidative Degradation of Favipiravir by Electrogenerated Superoxide through Proton-Coupled Electron Transfer
Tatsushi Nakayama, Ryo Honda
Abstract
through the PCET mechanism in the immune system. This mechanistic study implies that the oxidative degradation of pyrazine derivatives will be prevented by controlling the PCET through simple modification of the pyrazine structure.
Topics & Concepts
PyrazineFavipiravirChemistrySuperoxideElectron transferProton-coupled electron transferNucleobaseOxidative phosphorylationPhotochemistryStereochemistryBiochemistryMedicineEnzymeDiseaseDNAInfectious disease (medical specialty)PathologyCoronavirus disease 2019 (COVID-19)Electrochemical Analysis and ApplicationsConducting polymers and applicationsElectron Spin Resonance Studies