Advances in Xmipp for Cryo–Electron Microscopy: From Xmipp to Scipion
David Střelák, Amaya Jiménez-Moreno, José Luis Vilas, Erney Ramírez-Aportela, Rubén Sánchez-García, David Maluenda, Javier Vargas, David Herreros, E. Fernández-Giménez, F.P. de Isidro-Gómez, J. Horáček, David Myška, Martin Horáček, Pablo Conesa, Yunior César Fonseca-Reyna, Jorge Jiménez, Marta Martínez, Mohamad Harastani, Slavica Jonić, Jiří Filipovič, R. Marabini, J.M. Carazo, Carlos Óscar S. Sorzano
Abstract
Xmipp is an open-source software package consisting of multiple programs for processing data originating from electron microscopy and electron tomography, designed and managed by the Biocomputing Unit of the Spanish National Center for Biotechnology, although with contributions from many other developers over the world. During its 25 years of existence, Xmipp underwent multiple changes and updates. While there were many publications related to new programs and functionality added to Xmipp, there is no single publication on the Xmipp as a package since 2013. In this article, we give an overview of the changes and new work since 2013, describe technologies and techniques used during the development, and take a peek at the future of the package.