Base-controlled selective cleavage of the C–F bond of difluorocarbene for the divergent assembly of indolizines
Chun‐Yan Wu, Xiang‐Long Chen, Dongsheng Yang, Yong‐Xing Tang, Lisheng Wang, Yan‐Dong Wu, Shi‐Yi Zhuang, An‐Xin Wu
Abstract
A [3 + 1 + 1] cascade annulation reaction for the divergent construction of trisubstituted indolizines using sulfoxonium ylides, BrCF 2 CO 2 Me and pyridinium salts as readily available substrates has been developed.
Topics & Concepts
DifluorocarbeneAnnulationPyridiniumChemistryCascadeCleavage (geology)Bond cleavageCombinatorial chemistryMedicinal chemistryBase (topology)Cascade reactionOrganic chemistryCatalysisEngineeringGeotechnical engineeringMathematical analysisMathematicsFracture (geology)ChromatographySynthesis and Reactivity of HeterocyclesCyclopropane Reaction MechanismsFluorine in Organic Chemistry