Navigating the complexities of drug development for metallo-β-lactamase inhibitors
Nakita Reddy, Alessandra Moraes Balieiro, José Rogério A. Silva, Christiaan A. Gouws, Awelani Mutshembele, Per I. Arvidsson, Hendrik G. Kruger, Thavendran Govender, Tricia Naicker
Abstract
Standardized approaches to MBL inhibitor development are vital. This work highlights the benefits of uniform methodologies while addressing key preclinical challenges to bridge the gap toward successful clinical translation.
Topics & Concepts
DrugDrug developmentPharmacologyMedicineAntibiotic Resistance in BacteriaTuberculosis Research and EpidemiologyAntibiotic Use and Resistance