Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling
Shadid Uz Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li
Abstract
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
Topics & Concepts
Wnt signaling pathwayColorectal cancerCancer stem cellCateninCancer researchStem cellDegradation (telecommunications)Beta-cateninCell biologyMedicineChemistryCancerSignal transductionBiologyInternal medicineComputer scienceTelecommunicationsProtein Degradation and InhibitorsHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and Analysis