The supramolecular self-assembly of 5-fluorouracil and caffeic acid through cocrystallization strategy opens up a new way for the development of synergistic antitumor pharmaceutical cocrystal
Yue‐Ming Yu, Ling‐Yang Wang, Fan-Zhi Bu, Lin‐Lin Wang, Yan‐Tuan Li, Cheng Wang, Zhi‐Yong Wu
Abstract
Cocrystallizing with caffeic acid (CF) provides a new strategy for effectually optimizing <italic>in vivo</italic>/vitro properties of anticancer drug 5-fluorouracil (FL).
Topics & Concepts
CocrystalCaffeic acidSupramolecular chemistryChemistryAnticancer drugFluorouracilCombinatorial chemistryIn vivoIn vitroStereochemistryDrugPharmacologyOrganic chemistryBiochemistryMoleculeMedicineBiologyHydrogen bondBiotechnologyAntioxidantSurgeryChemotherapyCrystallography and molecular interactionsEnzyme Structure and FunctionCrystal structures of chemical compounds