High-Dose Acetaminophen with Concurrent CYP2E1 Inhibition Has Profound Anticancer Activity without Liver Toxicity
Allyn Bryan, Pavani Pingali, Anthony C. Faber, Joseph W. Landry, Jephte Y. Akakpo, Hartmut Jaeschke, Howard Li, Won Sok Lee, Lauren May, Bhaumik B. Patel, Alex Neuwelt
Topics & Concepts
PharmacologyToxicityAcetaminophenMedicineCYP2E1In vivoMetaboliteChemistryMetabolismInternal medicineCytochrome P450BiologyBiotechnologyPharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and ProtectionEicosanoids and Hypertension Pharmacology