Gut microbiota-derived metabolites as key mucosal barrier modulators in obesity
Yanxia Wei, Kuiyang Zheng, Yugang Wang
Abstract
, dysbiosis, are thought to drive obesity-related pathogenesis and may be one of the most important drivers of mucosal barrier dysfunction. Many effects of the microbiota on the host are mediated by microbiota-derived metabolites. In this review, we focus on several relatively well-studied microbial metabolites that can influence intestinal mucosal homeostasis and discuss how they might affect metabolic diseases. The design and use of microbes and their metabolites that are locally active in the gut without systemic side effects are promising novel and safe therapeutic modalities for metabolic diseases.
Topics & Concepts
Gut floraObesityKey (lock)MicrobiologyBiologyChemistryImmunologyEndocrinologyEcologyGut microbiota and healthDiet and metabolism studiesDietary Effects on Health