Ru(II)-Catalyzed C–H Hydroxyalkylation and Mitsunobu Cyclization of <i>N</i>-Aryl Phthalazinones
Kunyoung Kim, Sang Hoon Han, Daeun Jeoung, Prithwish Ghosh, Saegun Kim, Seung‐Jun Kim, Jin‐Mo Ku, Neeraj Kumar Mishra, In Su Kim
Abstract
-aryl phthalazinones with a range of aldehydes and activated ketone is described. Initial formation of hydroxyalkylated phthalazinones and subsequent Mitsunobu cyclization provided facile access to biologically relevant indazolophthalazinones. The utility of this method is highlighted by synthetic transformations into a series of potentially bioactive scaffolds.
Topics & Concepts
ChemistryKetoneArylRutheniumCatalysisCombinatorial chemistryMitsunobu reactionOrganic chemistryAldehydeSurface modificationPhysical chemistryAlkylCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSynthesis and Catalytic Reactions