Stereodivergent access to all four stereoisomers of chiral tetrahydrobenzo[<i>f</i>][1,4]oxazepines, through highly diastereoselective multicomponent Ugi–Joullié reaction
Alessandro Pinna, Andrea Basso, Chiara Lambruschini, Lisa Moni, Renata Riva, Valeria Rocca, Luca Banfi
Abstract
isomer may also be attained, thanks to a thermodynamically controlled base catalysed epimerization. Free secondary amines have been obtained using an unprecedented "removable" carboxylic acid.
Topics & Concepts
ChemistryStereochemistryCombinatorial chemistryMedicinal chemistryMulticomponent Synthesis of HeterocyclesSynthesis and Biological ActivitySynthesis of β-Lactam Compounds