Fibroblasts facilitate lymphatic vessel formation in transplanted heart
Hui Gong, Ting Wang, Xiaotong Sun, Yuesheng Zhang, Yichao Qiu, Wenlong Sun, Yue Zhang, Peng Teng, Yanhua Hu, Xiaosheng Hu, Liang Ma, Qingbo Xu, Haige Zhao
Abstract
Our study indicates that cardiac lymphangiogenesis primarily originates from recipient cells, and activated fibroblasts play a crucial role in facilitating the generation of lymphatic vessels after heart transplantation. These findings provide valuable insights into potential therapeutic targets for enhancing graft survival.
Topics & Concepts
LymphangiogenesisLymphatic systemLymphatic EndotheliumTransplantationLymphatic vesselHeart transplantationCell biologyPathologyCancer researchBiologyMedicineInternal medicineCancerMetastasisLymphatic System and DiseasesCongenital heart defects researchMesenchymal stem cell research