Circulating monocytes associated with anti-PD-1 resistance in human biliary cancer induce T cell paralysis
Bridget P. Keenan, Elizabeth McCarthy, Arielle Ilano, Hai Yang, Li Zhang, Kathryn M. Allaire, Zenghua Fan, Tony Li, David Lee, Yang Sun, Alexander Cheung, Diamond Luong, Hewitt Chang, Brandon Chen, Jaqueline Marquez, Brenna Sheldon, Robin Kate Kelley, Chun Ye, Lawrence Fong
Abstract
gene signature associates with worse survival in patients with BTC as well as in other anti-PD-1 refractory cancers. These results demonstrate that monocytes arising after anti-PD-1 treatment can induce T cell paralysis as a distinct mode of tumor-mediated immunosuppression leading to CPI resistance.
Topics & Concepts
CD14ImmunotherapyMyeloidImmunologyCancer researchMedicinePeripheral blood mononuclear cellBiologyImmune systemBiochemistryIn vitroCancer Immunotherapy and BiomarkersImmune cells in cancerCholangiocarcinoma and Gallbladder Cancer Studies