Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model
Zahra Aghababaie, Leo K. Cheng, Niranchan Paskaranandavadivel, Recep Avci, Chih-Hsiang Alexander Chan, Ashton Matthee, Satya Amirapu, Samuel J. Asirvatham, Gianrico Farrugia, Arthur Beyder, Gregory O’Grady, Timothy R. Angeli
Abstract
This study presents gastric ablation as a novel tool for modulating gastric bioelectrical activation, including eliminating the normal gastric pacemaker site as well as abnormal ectopic pacemaker sites underlying gastric dysrhythmias. Targeted application of radiofrequency ablation was able to eliminate these pacemaker sites without disrupting surrounding conduction capability or tissue structure. Gastric ablation presents a powerful new research tool for modulating gastric electrical activation and may likely hold therapeutic potential for disorders of gastric function.