Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA<sub>1</sub>) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases
Peter T. W. Cheng, Robert F. Kaltenbach, Hao Zhang, Jun Shi, Shiwei Tao, Jun Li, Lawrence J. Kennedy, Steven J. Walker, Yan Shi, Ying Wang, Suresh Dhanusu, Ramesh Reddigunta, K. Selvakumar, Sutjano Jusuf, Daniel Smith, Subramaniam Krishnananthan, Jianqing Li, Tao Wang, Rebekah Heiry, Chi Shing Sum, Stephen Kalinowski, Chen-Pin Hung, Ching-Hsuen Chu, Anthony V. Azzara, Milinda Ziegler, Lisa Burns, Bradley A. Zinker, Stephanie Boehm, Joseph R. Taylor, Julia Sapuppo, Kathy Mosure, Gerry Everlof, Victor R. Guarino, Lisa Zhang, Yanou Yang, Qian Ruan, Carrie Xu, Atsu Apedo, Sarah C. Traeger, Mary Ellen Cvijic, Kimberley A. Lentz, Giridhar Tirucherai, Lakshmi Sivaraman, Jeffrey A. Robl, Bruce A. Ellsworth, Glenn D. Rosen, David A. Gordon, Matthew G. Soars, Michael Gill, Brian J. Murphy
Abstract
was advanced into clinical trials, including an ongoing Phase 2 clinical trial in patients with lung fibrosis (NCT04308681).