Deconstructive Cycloaromatization Strategy toward <i>N</i>,<i>O</i>-Bidentate Ligands from Indolizines and Cyclopropenones
Jinlei Zhou, Xiaotian Shi, Huitao Zheng, Guangxian Chen, Chen Zhang, Xiang Liu, Hua Cao
Abstract
The innovative construction of novel N,O-bidentate ligands represents a long-standing challenge for chemists. Here, we report an unprecedented approach for the construction of N,O-bidentate derivatives via the merging of ring deconstruction with cycloaromatization of indolizines and cyclopropenones. Without any catalysts, our method can deliver a series of polyaryl 2-(pyridin-2-yl)phenols in excellent yields. In addition, N,O-bidentate organic BF2 complexes can also be constructed via this one-pot protocol.
Topics & Concepts
DenticityChemistryRing (chemistry)PhenolsPhenolStereochemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryCrystal structureSynthesis and Reactivity of HeterocyclesCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods