Discovery of [<sup>11</sup>C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases
Ling Tong, Wenping Li, Michael Man‐Chu Lo, Xiaolei Gao, Jenny Wai, Michael T. Rudd, David M. Tellers, Aniket Joshi, Zhizhen Zeng, Patricia Miller, Cristian Salinas, Kerry Riffel, Hyking Haley, Mona Purcell, Marie A. Holahan, Liza Gantert, Jeffrey W. Schubert, Kristen L. Jones, James Mulhearn, Melissa S. Egbertson, Zhaoyang Meng, Barbara Hanney, Robert Gomez, Scott T. Harrison, Paul McQuade, Tjerk Bueters, Jason M. Uslaner, John A. Morrow, Fiona Thomson, Jongrock Kong, Jing Liao, Oleg Selyutin, Jianming Bao, Nicholas B. Hastings, Sony Agrawal, Brian C. Magliaro, Frederick J. Monsma, Michelle Smith, Stefania Risso, David Hesk, Eric D. Hostetler, Robert Mazzola
Abstract
C]MK-6884.
Topics & Concepts
Allosteric regulationIn vivoChemistryPositron emission tomographyAllosteric modulatorReceptorAgonistPreclinical imagingMuscarinic acetylcholine receptorBiophysicsMolecular imagingPharmacologyNeuroscienceBiochemistryMedicinePsychologyBiologyBiotechnologyReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology ResearchNeuropeptides and Animal Physiology