Sustained inhibition of PARP-1 activity delays glioblastoma recurrence by enhancing radiation-induced senescence
Atanu Ghorai, Tejashree Mahaddalkar, Rahul Thorat, Shilpee Dutt
Topics & Concepts
Poly ADP ribose polymeraseSenescenceCancer researchPARP inhibitorOlaparibIn vivoBiologyRadiation therapyClonogenic assayRadiation sensitivityMedicineInternal medicineCell biologyGeneticsPolymeraseGenePhysicsIrradiationNuclear physicsPARP inhibition in cancer therapyDNA Repair MechanismsTelomeres, Telomerase, and Senescence