Synthesis of difluoromethylated spiropyrazolones <i>via</i> [3 + 2] cycloaddition of difluoroacetohydrazonoyl bromides with alkylidene pyrazolones
Yang Feng, Yuanyuan Ren, Duoduo Tang, Ke‐Hu Wang, Junjiao Wang, Danfeng Huang, Xiaobo Lv, Yulai Hu
Abstract
Highly functionalized fluoroalkyl spiropyrazolones are synthesized via an effective [3 + 2] cycloaddition of di/trifluoromethyl hydrazonoyl bromides and alkylidene pyrazolones in good yields.
Topics & Concepts
PyrazolonesCycloadditionTrifluoromethylChemistryMedicinal chemistryOrganic chemistryCatalysisAlkylFluorine in Organic ChemistrySynthesis and Biological EvaluationSynthesis and Reactions of Organic Compounds