ALDH2 is a prognostic biomarker and related with immune infiltrates in HCC.
Senbang Yao, Xiangxiang Yin, Tingting Chen, Wenjun Chen, Hao Zuo, Ziran Bi, Xiuqing Zhang, Yanyan Jing, Lulian Pang, Huaidong Cheng
Abstract
<0.05). A nomogram was designed using expression of ALDH2 and clinical factors. ALDH2 was correlated with dendritic cells and macrophages in immune infiltration. In conclusion, ALDH2 has significant prognostic value in hepatocellular carcinoma and they may play key roles in regulating tumor progression and the immune cells infiltration. Our results suggest that ALDH2 may be a new type of tumor biomarker, which can be used to judge the prognosis, targeted therapy and immunotherapy of patients with HCC.
Topics & Concepts
ALDH2Hepatocellular carcinomaAldehyde dehydrogenaseImmunohistochemistryCancer researchBiomarkerImmune systemMedicinePathologicalLiver cancerPathologyBiologyGeneImmunologyGeneticsFerroptosis and cancer prognosisCancer Cells and MetastasisCancer, Hypoxia, and Metabolism