Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies
Luca Docci, Nicolò Milani, Thomas Ramp, Andrea A. Romeo, Patrício Godoy, Daniela Ortiz Franyuti, Stephan Krähenbühl, Michael Gertz, Aleksandra Galetin, Neil Parrott, Stephen Fowler
Abstract
Microphysiological systems (MPS) are complex and more physiologically realistic cellular in vitro tools that aim to provide more relevant human in vitro data for quantitative prediction of clinical pharmacokinetics while also reducing the need for animal testing.
Topics & Concepts
Drug metabolismDrugChipMetabolismComputational biologyComputer scienceEngineeringChemistryPharmacologyBiologyBiochemistryElectrical engineering3D Printing in Biomedical ResearchInnovative Microfluidic and Catalytic Techniques InnovationPharmacogenetics and Drug Metabolism