Deciphering the Mrr1/Mdr1 Pathway in Azole Resistance of Candida auris
Jizhou Li, Alix T. Coste, Daniel Bachmann, Dominique Sanglard, Frédéric Lamoth
Abstract
Candida auris is an emerging yeast pathogen with a remarkable ability to develop antifungal resistance, in particular to fluconazole and other azoles. Azole resistance in C. auris was shown to result from different mechanisms, such as mutations in the target gene ERG11 or gain-of-function (GOF) mutations in the transcription factor TAC1b and overexpression of the drug transporter Cdr1.
Topics & Concepts
Candida aurisAzoleFluconazoleBiologyMicrobiologyMutantDrug resistanceGeneGeneticsAntifungalAntifungal resistance and susceptibilityFungal Infections and StudiesPneumocystis jirovecii pneumonia detection and treatment